INTER-EWING-1 (Ewing sarcoma)

Recruiting

Who can enter

• Children and young adults with newly diagnosed Ewing sarcoma 

• Age: over two years old at diagnosis

Goal

The goal of this study is to improve the treatment of patients with newly diagnosed Ewing sarcoma. 

Background

Currently, we cannot cure all patients with Ewing sarcoma. Therefore, we want to improve treatment and conduct more research into the diagnosis and treatment of children and young adults with Ewing sarcoma. To do this, we want to register medical data of all these children and young adults. We also use imaging ("scans") for research.

During different parts of the treatment we investigate whether we can improve the standard treatment. We then compare the usual treatment with a modified treatment. Depending on the diagnosis and treatment, participants may participate in one or more of these research questions during treatment. These are the different research questions:

• Induction chemotherapy: During the first courses of chemotherapy, we want to investigate whether adding the drug regorafenib improves treatment outcome.

• Radiotherapy: During radiotherapy, we want to investigate the optimal dose of radiotherapy. 

• Maintenance therapy: After the standard treatment is completed, we want to investigate whether adding 6 months of maintenance therapy with the drugs cyclophosphamide and vinorelbine causes the disease to relapse in fewer patients.

In order to participate in a study please refer to your/your child’s doctor.
For international patients: please feel welcome to contact our International Patients Office.

Last reviewed

March 12, 2026

The above information is intended as a brief summary only and may not reflect the most up-to-date information. For full details and the current status of a protocol, physicians can contact the Princess Máxima Center directly.