BRAINatomy 2 (braintumors)
Clinical study on how proton radiotherapy affects the thinking of children and young adults who have been treated for a brain tumor.
Recruiting
Who can enter
Children and young adults who have had a brain tumor and were treated with proton radiotherapy at the University Medical Center Groningen more than three years ago
Age: 6 years and older
Goal
Goal
This study looks at how proton radiotherapy affects the thinking skills of children and young adults who have had brain tumor treatment. By thinking, we mean for example how well you can concentrate or remember things. The aim is to find out which parts of the brain are most affected by proton radiotherapy. We hope to improve proton radiotherapy to avoid damaging sensitive brain areas. It also helps to identify early those who might have problems with thinking skills after treatment.
Background
Background
Proton radiotherapy may cause less long-term damage to the brain compared to standard radiotherapy. However, some still experience lasting damage, such as difficulty processing and learning new information or difficulty to remember information. Research on vulnerable brain areas has previously been done for standard radiotherapy. Since proton radiotherapy works differently, we will now study this for proton radiotherapy.
For this research, we ask children and young adults to do a few tasks once at the Princess Máxima Center. We will ask you to remember things or solve puzzles, for example. We will ask parents to fill out online questionnaires in the KLIK portal. Additionally, existing MRI scans and other treatment information from the University Medical Center Groningen will be used.
In order to participate in a study please refer to your/your child’s doctor.
Last reviewed
Last reviewed
November 13, 2025
Study details
- Study details
Official title
BRAINatomy 2: A prospective study of late cognitive effects and imaging changes after proton radiotherapy Cancer type BraintumorsMaximum number of participants
250, of whom 75 are expected to participate in the NetherlandsStart date
November 13, 2025Status
OpenLocal principal investigator
Dr. Marita PartanenSponsor
University of ManchesterApproval
This study has been reviewed and approved by the internal scientific committee (Clinical Research Committee) of the Princess Máxima Center. An accredited medical research ethics committee waived the need for official approval according to the Medical Research Involving Human Subjects Act (WMO), and is therefore not further involved in the review of the research. This is only done for studies with low risk or low patient burden. More information can be found at: CCMO.
The above information is intended as a brief summary only and may not reflect the most up-to-date information. For full details and the current status of a protocol, physicians can contact the Princess Máxima Center directly.